K-Ras(G12D)-selective inhibitory peptides generated by random peptide T7 phage display technology

Kotaro Sakamoto, Yusuke Kamada, Tomoya Sameshima, +9

Biochemical and Biophysical Research Communications

BiochemistryMedicineNatural SciencesPeptide EngineeringPeptide Library +7

Anti‐tumor efficacy of a novel CLK inhibitor via targeting RNA splicing and MYC‐dependent vulnerability

Kenichi Iwai, Masahiro Yaguchi, Kazuho Nishimura, +23

EMBO Molecular Medicine

Investigation of the structural requirements of K-Ras(G12D) selective inhibitory peptide KRpep-2d using alanine scans and cysteine bridging

Ayumu Niida, Shigekazu Sasaki, Kazuko Yonemori, +5

Bioorganic & Medicinal Chemistry Letters

Alanine ScansMedicinal ChemistryBiochemistryStructural RequirementsNatural Sciences +8

Direct Evidence of Abortive Lytic Infection-Mediated Establishment of Epstein-Barr Virus Latency During B-Cell Infection

Tomoki Inagaki, Yoshitaka Sato, Jumpei Ito, +9

Frontiers in Microbiology

Transcriptional RegulationMolecular VirologyEbv LatencyViral PersistenceEpstein-barr Virus Latency +13

Antitumor Activity of TAK-285, an Investigational, Non-Pgp Substrate HER2/EGFR Kinase Inhibitor, in Cultured Tumor Cells, Mouse and Rat Xenograft Tumors, and in an HER2-Positive Brain Metastasis Model

Akiko Nakayama, Shinji Takagi, Tadashi Yusa, +6

Journal of Cancer

Neuro-oncologyAntitumor ActivityChemoprevention StrategyMedicineBreast Cancer Therapy +13

Discovery of novel serine palmitoyltransferase inhibitors as cancer therapeutic agents

Takuto Kojima, Yasutomi Asano, Osamu Kurasawa, +21

Bioorganic & Medicinal Chemistry

Cancer Therapeutic AgentsMedicineAnti-cancer AgentDrug DevelopmentBiomolecular Engineering +4

Antitumor activity of a novel and orally available inhibitor of serine palmitoyltransferase

Masahiro Yaguchi, Sachio Shibata, Yoshinori Satomi, +8

Biochemical and Biophysical Research Communications

Medicinal ChemistryAntitumor ActivityMedicineSerine PalmitoyltransferaseAvailable Inhibitor +8

Epstein–Barr virus tegument protein BGLF2 in exosomes released from virus-producing cells facilitates de novo infection

Yoshitaka Sato, Masahiro Yaguchi, Yusuke Okuno, +10

Cell Communication and Signaling

Identification and characterization of the variants of metastasis-associated protein 1 generated following alternative splicing

Masahiro Yaguchi, Yoriko Wada, Yasushi Toh, +4

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression

Somatic VariantMedicinePathologyCancer GenomicsSystems Biology +5