Tadashi Yusa

Design and synthesis of novel pyrimido[4,5-b]azepine derivatives as HER2/EGFR dual inhibitors

Youichi Kawakita, Masaki Seto, Tomohiro Ohashi et al. · Bioorganic & Medicinal Chemistry · 2013 · 72 citations · Full text

Design and Synthesis of Pyrrolo[3,2-<i>d</i>]pyrimidine Human Epidermal Growth Factor Receptor 2 (HER2)/Epidermal Growth Factor Receptor (EGFR) Dual Inhibitors: Exploration of Novel Back-Pocket Binders

Youichi Kawakita, Hiroshi Banno, Tomohiro Ohashi et al. · Journal of Medicinal Chemistry · 2012 · 42 citations · Full text

Design and synthesis of pyrrolo[3,2-d]pyrimidine HER2/EGFR dual inhibitors: Improvement of the physicochemical and pharmacokinetic profiles for potent in vivo anti-tumor efficacy

Youichi Kawakita, Kazuhiro Miwa, Masaki Seto et al. · Bioorganic & Medicinal Chemistry · 2012 · 27 citations · Full text

Medicinal Chemistry, Medicine, Pharmacokinetic Profiles +9

Antitumor Activity of TAK-285, an Investigational, Non-Pgp Substrate HER2/EGFR Kinase Inhibitor, in Cultured Tumor Cells, Mouse and Rat Xenograft Tumors, and in an HER2-Positive Brain Metastasis Model

Akiko Nakayama, Shinji Takagi, Tadashi Yusa et al. · Journal of Cancer · 2013 · 24 citations · Full text

Neuro-oncology, Antitumor Activity, Chemoprevention Strategy +15