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Design and synthesis of pyrrolo[3,2-d]pyrimidine HER2/EGFR dual inhibitors: Improvement of the physicochemical and pharmacokinetic profiles for potent in vivo anti-tumor efficacy

Medicinal ChemistryMedicinePharmacokinetic ProfilesVivo Anti-tumor EfficacyPharmacotherapyAnti-cancer AgentDrug DevelopmentPharmacologyRadiation OncologyPharmaceutical ChemistryCancer ResearchDrug Discovery