Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571).

Bhushan Nagar, William G. Bornmann, Patricia Pellicena, +5

PubMed

Crystal StructureMixed-phenotype Acute LeukemiaMolecular BiologyTumor BiologyMyeloid Neoplasia +16

Structural Basis for the Autoinhibition of c-Abl Tyrosine Kinase

Bhushan Nagar, Oliver Hantschel, Matthew A. Young, +6

Cell

C-abl Tyrosine KinaseSignal TransductionBiochemistryMolecular RegulationNatural Sciences +5

Structural basis of calcium-induced E-cadherin rigidification and dimerization

Bhushan Nagar, Michael Overduin, Mitsuhiko Ikura, +1

Nature

Protein FoldingCell AdhesionConformational StudyCalcium-induced E-cadherin RigidificationMedicine +2

Structural basis for 5′-nucleotide base-specific recognition of guide RNA by human AGO2

Filipp Frank, Nahum Sonenberg, Bhushan Nagar

Nature

Guide RnaNatural SciencesGeneticsRna Structure PredictionRna Biology +7

Structure of Parkin Reveals Mechanisms for Ubiquitin Ligase Activation

Jean-François Trempe, Véronique Sauvé, Karl Grenier, +10

Science

A Myristoyl/Phosphotyrosine Switch Regulates c-Abl

Oliver Hantschel, Bhushan Nagar, Sebastian Guettler, +4

Cell

Signal TransductionMolecular RegulationNatural SciencesMyristoyl/phosphotyrosine SwitchMolecular Biology +7

Structural Evidence for Feedback Activation by Ras·GTP of the Ras-Specific Nucleotide Exchange Factor SOS

S.M. Margarit, Holger Sondermann, Brian E. Hall, +5

Cell

Signal TransductionMolecular PhysiologyBiochemistryStructural EvidenceNatural Sciences +6

miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4–NOT

Marc R. Fabian, Maja K. Cieplak-Rotowska, Filipp Frank, +8

Nature Structural & Molecular Biology

Transcriptional RegulationMirna-mediated DeadenylationNatural SciencesRna BiologyMolecular Biology +6

Structural basis for the recruitment of the human CCR4–NOT deadenylase complex by tristetraprolin

Marc R. Fabian, Filipp Frank, Christopher Rouya, +6

Nature Structural & Molecular Biology

Protein FunctionBiochemistryProtein AssemblyNatural SciencesMolecular Biology +4

Structural basis for viral 5′-PPP-RNA recognition by human IFIT proteins

Y.M. Abbas, Andreas Pichlmair, Maria W. Górna, +2

Nature

Virus StructureViral ReplicationViral Polymerase StructureNatural SciencesViral Polymerase Mechanism +8