Yoshikazu Ohta

Structural Analysis of the Mechanism of Inhibition and Allosteric Activation of the Kinase Domain of HER2 Protein

Kathleen Aertgeerts, R.J. Skene, Jason K. Yano et al. · Journal of Biological Chemistry · 2011 · 414 citations · Full text

Crystal Structure, Molecular Biology, Cancer Biology +22

Design and Synthesis of Novel Human Epidermal Growth Factor Receptor 2 (HER2)/Epidermal Growth Factor Receptor (EGFR) Dual Inhibitors Bearing a Pyrrolo[3,2-<i>d</i>]pyrimidine Scaffold

Tomoyasu Ishikawa, Masaki Seto, Hiroshi Banno et al. · Journal of Medicinal Chemistry · 2011 · 207 citations · Full text

Dual Inhibitors Bearing, Medicinal Chemistry, Dual Inhibitors +12

Structure-Based Approach for the Discovery of Pyrrolo[3,2-<i>d</i>]pyrimidine-Based EGFR T790M/L858R Mutant Inhibitors

Satoshi Sogabe, Youichi Kawakita, S. Igaki et al. · ACS Medicinal Chemistry Letters · 2012 · 161 citations · Full text

Molecular Biology, Egfr Inhibitors, Chemical Biology +19

Studies on Disease-Modifying Antirheumatic Drugs:  Synthesis of Novel Quinoline and Quinazoline Derivatives and Their Anti-inflammatory Effect

Atsuo Baba, Noriaki Kawamura, Haruhiko Makino et al. · Journal of Medicinal Chemistry · 1996 · 149 citations

Novel Quinoline, Aa Rat Model, Antiparasitic Agent +17

Design and synthesis of novel pyrimido[4,5-b]azepine derivatives as HER2/EGFR dual inhibitors

Youichi Kawakita, Masaki Seto, Tomohiro Ohashi et al. · Bioorganic & Medicinal Chemistry · 2013 · 72 citations · Full text