Tomohiro Ohashi

CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor

Tyler Funnell, Shinya Tasaki, Arusha Oloumi et al. · Nature Communications · 2017 · 134 citations · Full text

Design and Synthesis of Novel DFG-Out RAF/Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) Inhibitors. 1. Exploration of [5,6]-Fused Bicyclic Scaffolds

Masanori Okaniwa, Masaaki Hirose, Takashi Imada et al. · Journal of Medicinal Chemistry · 2012 · 76 citations

Design and synthesis of novel pyrimido[4,5-b]azepine derivatives as HER2/EGFR dual inhibitors

Youichi Kawakita, Masaki Seto, Tomohiro Ohashi et al. · Bioorganic & Medicinal Chemistry · 2013 · 72 citations · Full text

Discovery of the investigational drug TAK-441, a pyrrolo[3,2-c]pyridine derivative, as a highly potent and orally active hedgehog signaling inhibitor: Modification of the core skeleton for improved solubility

Tomohiro Ohashi, Yuya Oguro, Toshio Tanaka et al. · Bioorganic & Medicinal Chemistry · 2012 · 71 citations · Full text

Medicinal Chemistry, Pharmaceutical Science, Active Hedgehog +13

Discovery of pyrrolo[3,2-c]quinoline-4-one derivatives as novel hedgehog signaling inhibitors

Tomohiro Ohashi, Yuya Oguro, Toshio Tanaka et al. · Bioorganic & Medicinal Chemistry · 2012 · 64 citations · Full text

Medicinal Chemistry, Medicine, Novel Hedgehog +4