The clonal and mutational evolution spectrum of primary triple-negative breast cancers

Sohrab P. Shah, Andrew Roth, Rodrigo Goya, +56

Nature

Breast OncologyTumor HeterogeneityMedicinePathologyCancer Genomics +8

<i>ARID1A</i> Mutations in Endometriosis-Associated Ovarian Carcinomas

Kimberly C. Wiegand, Sohrab P. Shah, Osama M. Al‐Agha, +41

New England Journal of Medicine

Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors

Yuanmei Lou, Paul C. McDonald, Arusha Oloumi, +21

Cancer Research

Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution

Peter Eirew, Adi Steif, Jaswinder Khattra, +43

Nature

XenotransplantationSomatic VariantTumor HeterogeneitySingle-cell ResolutionMedicine +10

Ordering of mutations in preinvasive disease stages of esophageal carcinogenesis

Jamie Weaver, Caryn S. Ross-Innes, Nicholas B. Shannon, +25

Nature Genetics

Esophageal CarcinogenesisSomatic VariantEsophageal CancerEsophagusMedicine +5

Integrative analysis of genome-wide loss of heterozygosity and monoallelic expression at nucleotide resolution reveals disrupted pathways in triple-negative breast cancer

Gavin Ha, Andrew Roth, Daniel Lai, +14

Genome Research

Breast OncologyGeneticsTranscriptomics TechnologyIntegrative AnalysisTumor Biology +14

Rictor and Integrin-Linked Kinase Interact and Regulate Akt Phosphorylation and Cancer Cell Survival

Paul C. McDonald, Arusha Oloumi, Julia Mills, +7

Cancer Research

JointSNVMix: a probabilistic model for accurate detection of somatic mutations in normal/tumour paired next-generation sequencing data

Andrew Roth, Jiarui Ding, Ryan D. Morin, +10

Bioinformatics

CDK12 regulates alternative last exon mRNA splicing and promotes breast cancer cell invasion

Jerry F. Tien, Alborz Mazloomian, Siwei Cheng, +11

Nucleic Acids Research

Systems BiologySignaling PathwayCell RegulationMedicineGene Expression +13

Feature-based classifiers for somatic mutation detection in tumour–normal paired sequencing data

Jiarui Ding, Ali Bashashati, Andrew Roth, +9

Bioinformatics