Yuya Oguro

Design, synthesis, and evaluation of 5-methyl-4-phenoxy-5H-pyrrolo[3,2-d]pyrimidine derivatives: Novel VEGFR2 kinase inhibitors binding to inactive kinase conformation

Yuya Oguro, Naoki Miyamoto, Kengo Okada et al. · Bioorganic & Medicinal Chemistry · 2010 · 122 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Discovery of N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-methylphenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide (TAK-593), a highly potent VEGFR2 kinase inhibitor

Naoki Miyamoto, Nozomu Sakai, Takaharu Hirayama et al. · Bioorganic & Medicinal Chemistry · 2013 · 72 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +10

Discovery of the investigational drug TAK-441, a pyrrolo[3,2-c]pyridine derivative, as a highly potent and orally active hedgehog signaling inhibitor: Modification of the core skeleton for improved solubility

Tomohiro Ohashi, Yuya Oguro, Toshio Tanaka et al. · Bioorganic & Medicinal Chemistry · 2012 · 71 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Molecular mechanism and potential target indication of TAK-931, a novel CDC7-selective inhibitor

Kenichi Iwai, Tadahiro Nambu, Ryo Dairiki et al. · Science Advances · 2019 · 70 citations · Full text

Medicine, Oncology, Pharmacology +6

Discovery of pyrrolo[3,2-c]quinoline-4-one derivatives as novel hedgehog signaling inhibitors

Tomohiro Ohashi, Yuya Oguro, Toshio Tanaka et al. · Bioorganic & Medicinal Chemistry · 2012 · 64 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +8