Takaharu Hirayama

Aneuploidy generates proteotoxic stress and DNA damage concurrently with p53-mediated post-mitotic apoptosis in SAC-impaired cells

Akihiro Ohashi, Momoko Ohori, Kenichi Iwai et al. · Nature Communications · 2015 · 197 citations · Full text

Discovery of N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-methylphenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide (TAK-593), a highly potent VEGFR2 kinase inhibitor

Naoki Miyamoto, Nozomu Sakai, Takaharu Hirayama et al. · Bioorganic & Medicinal Chemistry · 2013 · 70 citations · Full text

Structure-based design, synthesis, and evaluation of imidazo[1,2-b]pyridazine and imidazo[1,2-a]pyridine derivatives as novel dual c-Met and VEGFR2 kinase inhibitors

Shigemitsu Matsumoto, Naoki Miyamoto, Takaharu Hirayama et al. · Bioorganic & Medicinal Chemistry · 2013 · 54 citations · Full text

Combinatorial Chemistry, Vegfr2 Kinase Inhibitors, Medicinal Chemistry +11

Design and synthesis of selective CDK8/19 dual inhibitors: Discovery of 4,5-dihydrothieno[3′,4′:3,4]benzo[1,2-d]isothiazole derivatives

Koji Ono, Hiroshi Banno, Masanori Okaniwa et al. · Bioorganic & Medicinal Chemistry · 2017 · 36 citations · Full text

Synthetic Studies on Centromere-Associated Protein-E (CENP-E) Inhibitors: 2. Application of Electrostatic Potential Map (EPM) and Structure-Based Modeling to Imidazo[1,2-<i>a</i>]pyridine Derivatives as Anti-Tumor Agents

Takaharu Hirayama, Masanori Okaniwa, Hiroshi Banno et al. · Journal of Medicinal Chemistry · 2015 · 35 citations

Drug Target, Bioorganic Chemistry, Chemical Biology +18