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Structure-based design, synthesis, and evaluation of imidazo[1,2-b]pyridazine and imidazo[1,2-a]pyridine derivatives as novel dual c-Met and VEGFR2 kinase inhibitors

Combinatorial ChemistryVegfr2 Kinase InhibitorsMedicinal ChemistryMedicineNatural SciencesRational Drug DesignOrganic ChemistryStructure-based DesignChemistryDrug DevelopmentNovel Dual C-metPharmacologyPharmaceutical ChemistryDrug Discovery