Philip A. Harris

Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases

Philip A. Harris, Scott B. Berger, Jae Uk Jeong et al. · Journal of Medicinal Chemistry · 2017 · 475 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Cutting Edge: RIP1 Kinase Activity Is Dispensable for Normal Development but Is a Key Regulator of Inflammation in SHARPIN-Deficient Mice

Scott B. Berger, Viera Kasparcova, Sandy Hoffman et al. · The Journal of Immunology · 2014 · 373 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

Discovery of 5-[[4-[(2,3-Dimethyl-2<i>H</i>-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a Novel and Potent Vascular Endothelial Growth Factor Receptor Inhibitor

Philip A. Harris, Amogh Boloor, Mui Cheung et al. · Journal of Medicinal Chemistry · 2008 · 345 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +15

Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death

Dan Weng, Robyn Marty-Roix, Sandhya Ganesan et al. · Proceedings of the National Academy of Sciences · 2014 · 298 citations · Full text

Life Sciences, Immunology, Microbiology +17

Autophagy protein ATG16L1 prevents necroptosis in the intestinal epithelium

Yu Matsuzawa, Yusuke Shono, Luis E. Gomez et al. · The Journal of Experimental Medicine · 2017 · 296 citations · Full text

Life Sciences, Cell Biology, Pathobiology +16