Design of amidobenzimidazole STING receptor agonists with systemic activity

Joshi M. Ramanjulu, G. Scott Pesiridis, Jingsong Yang, +42

Nature

Systemic ActivityMedicineMechanism Of ActionPharmacological AgentPharmacotherapy +2

RIP3 Induces Apoptosis Independent of Pronecrotic Kinase Activity

Pratyusha Mandal, Scott B. Berger, Sirika Pillay, +27

Molecular Cell

Cell RegulationPronecrotic Kinase ActivityReceptor Tyrosine KinaseApoptosisAutophagy +4

Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases

Philip A. Harris, Scott B. Berger, Jae Uk Jeong, +38

Journal of Medicinal Chemistry

Drug TargetImmunologyCell DeathPharmacotherapyInflammation +20

Cutting Edge: RIP1 Kinase Activity Is Dispensable for Normal Development but Is a Key Regulator of Inflammation in SHARPIN-Deficient Mice

Scott B. Berger, Viera Kasparcova, Sandy Hoffman, +12

The Journal of Immunology

DNA-Encoded Library Screening Identifies Benzo[<i>b</i>][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors

Philip A. Harris, Bryan W. King, Deepak Bandyopadhyay, +29

Journal of Medicinal Chemistry

Drug TargetImmunologyKinase InhibitorsMolecular BiologyCell Death +15

Bone Morphogenetic Protein Type IA Receptor Signaling Regulates Postnatal Osteoblast Function and Bone Remodeling

Yuji Mishina, Michael W. Starbuck, Michael A. Gentile, +8

Journal of Biological Chemistry

Characterization of GSK′963: a structurally distinct, potent and selective inhibitor of RIP1 kinase

SB Berger, Philip A. Harris, Rakesh Nagilla, +14

Cell Death Discovery

Discovery of GSK8612, a Highly Selective and Potent TBK1 Inhibitor

Douglas W. Thomson, Daniel Poeckel, Nico Zinn, +12

ACS Medicinal Chemistry Letters

Immune RegulationImmunologyImmunologic MechanismInnate ImmunityInflammation +22

MALT1 Protease Activity Is Required for Innate and Adaptive Immune Responses

Jong W. Yu, Sandy Hoffman, Allison M. Beal, +14

PLoS ONE

Adaptive Immune SystemInnate Immune SystemImmunologyImmune RegulationImmunologic Mechanism +25

Targeted Overexpression of Androgen Receptor in Osteoblasts: Unexpected Complex Bone Phenotype in Growing Animals

Kristine M. Wiren, Xiao-Wei Zhang, Amber R. Toombs, +4

Endocrinology

Androgen ReceptorComplex Bone PhenotypeSclerostinBone TissueReproductive Biology +15