Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases

Philip A. Harris, Scott B. Berger, Jae Uk Jeong, +38

Journal of Medicinal Chemistry

Drug TargetImmunologyCell DeathPharmacotherapyInflammation +20

Bromine-Catalyzed Aziridination of Olefins. A Rare Example of Atom-Transfer Redox Catalysis by a Main Group Element

Jae Uk Jeong, Beata Tao, Ingo Sagasser, +2

Journal of the American Chemical Society

Asymmetric CatalysisChemical EngineeringEngineeringAlkene MetathesisBiochemistry +13

DNA-Encoded Library Screening Identifies Benzo[<i>b</i>][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors

Philip A. Harris, Bryan W. King, Deepak Bandyopadhyay, +29

Journal of Medicinal Chemistry

Drug TargetImmunologyKinase InhibitorsMolecular BiologyCell Death +15

Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer

Philip A. Harris, Jill M. Marinis, John D. Lich, +25

ACS Medicinal Chemistry Letters

Biomimetic Total Syntheses of (+)-Cephalostatin 7, (+)-Cephalostatin 12, and (+)-Ritterazine K

Jae Uk Jeong, Scott C. Sutton, Seongkon Kim, +1

Journal of the American Chemical Society

Bioorganic ChemistryBiomimetic Total SynthesesAltmetric Attention ScoreChemical BiologyAltmetrics +19

Structure Activity Relationships of 5-, 6-, and 7-Methyl-Substituted Azepan-3-one Cathepsin K Inhibitors

Dennis S. Yamashita, Robert W. Marquis, Ren Xie, +28

Journal of Medicinal Chemistry

Combinatorial ChemistryMedicinal ChemistryPharmaceutical SciencePharmacological StudyBiochemistry +13

Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase

Philip A. Harris, Nicolas Faucher, Nicolas George, +50

Journal of Medicinal Chemistry

Drug TargetImmunologyEfficacious InhibitorsDrug ResistanceInflammation +17

Synthesis of the South Unit of Cephalostatin. 7. Total Syntheses of (+)-Cephalostatin 7, (+)-Cephalostatin 12, and (+)-Ritterazine K¹

Jae Uk Jeong, Chuangxing Guo, P. L. Fuchs

Journal of the American Chemical Society

Bioorganic ChemistryEngineeringOrganic ChemistryHeterocycle ChemistryTotal Syntheses +14

Preoperative chemoradiotherapy versus postoperative chemoradiotherapy for stage II–III resectable rectal cancer: a meta-analysis of randomized controlled trials

Jin Ho Song, Jae Uk Jeong, Jong Hoon Lee, +4

Radiation Oncology Journal

The Association between Shift Work and the Metabolic Syndrome in Female Workers

Han Hui Ye, Jae Uk Jeong, Man Joong Jeon, +1

Annals of Occupational and Environmental Medicine