Scott B. Berger

Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death

Pontus Ørning, Dan Weng, Kristian K. Starheim et al. · Science · 2018 · 1.1K citations · Full text

Life Sciences, Cell Biology, Immunology +17

RIP3 Induces Apoptosis Independent of Pronecrotic Kinase Activity

Pratyusha Mandal, Scott B. Berger, Sirika Pillay et al. · Molecular Cell · 2014 · 615 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +12

Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases

Philip A. Harris, Scott B. Berger, Jae Uk Jeong et al. · Journal of Medicinal Chemistry · 2017 · 475 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Cutting Edge: RIP1 Kinase Activity Is Dispensable for Normal Development but Is a Key Regulator of Inflammation in SHARPIN-Deficient Mice

Scott B. Berger, Viera Kasparcova, Sandy Hoffman et al. · The Journal of Immunology · 2014 · 373 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis

Nozomi Takahashi, Lars Vereecke, Mathieu J.M. Bertrand et al. · Nature · 2014 · 320 citations

Life Sciences, Cell Biology, Molecular Biology +12