A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment

Hannah Van Hove, Liesbet Martens, Isabelle Scheyltjens, +17

Nature Neuroscience

Cell LineageDevelopmental BiologySingle Cell SequencingMedicineTissue Environment +5

RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis

Nozomi Takahashi, Lars Vereecke, Mathieu J.M. Bertrand, +15

Nature

Intestinal HomeostasisReceptor Tyrosine KinaseApoptosisGastroenterologyCell Death +6

A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis

Mourad Matmati, Peggy Jacques, Jonathan Maelfait, +17

Nature Genetics

InflammationRheumatologyRheumatoid DisorderAutoimmune DiseaseImmunology +7

Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor–induced toxicity and experimental colitis

Lars Vereecke, Mozes Sze, Conor Mc Guire, +6

The Journal of Experimental Medicine

M-CSF and GM-CSF Receptor Signaling Differentially Regulate Monocyte Maturation and Macrophage Polarization in the Tumor Microenvironment

Eva Van Overmeire, Benoı̂t Stijlemans, Felix Heymann, +12

Cancer Research

ImmunologyBiological MicroenvironmentsImmunologic MechanismCell ProliferationImmunotherapy +15

ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation

Richard de Reuver, Simon Verdonck, Evelien Dierick, +13

Nature

Adar1 Prevents AutoinflammationSignal TransductionSignaling PathwayAutoantibody ProductionMedicine +2

Therapeutic depletion of CCR8⁺ tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-PD-1 therapy

Helena Van Damme, Bruno Dombrecht, Máté Kiss, +26

Journal for ImmunoTherapy of Cancer

<i>R</i><i>othia mucilaginosa</i>is an anti-inflammatory bacterium in the respiratory tract of patients with chronic lung disease

Charlotte Rigauts, Juliana Aizawa, Steven Taylor, +18

European Respiratory Journal

Pivotal Advance: Arginase-1-independent polyamine production stimulates the expression of IL-4-induced alternatively activated macrophage markers while inhibiting LPS-induced expression of inflammatory genes

Jan Van den Bossche, Wouter H. Lamers, Eleonore Koehler, +10

Journal of Leukocyte Biology

A20 controls intestinal homeostasis through cell-specific activities

Lars Vereecke, Sara Vieira‐Silva, Thomas Billiet, +12

Nature Communications

Intestinal HomeostasisAutoimmune DiseaseGut-organ AxisAutoimmunityGut Barrier +4