Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity

Rakesh Kumar, Victoria B. Knick, Sharon K. Rudolph, +15

Molecular Cancer Therapeutics

ImmunologyPharmacotherapyBolus AdministrationTumor BiologyAngiogenesis +15

Discovery of 5-[[4-[(2,3-Dimethyl-2<i>H</i>-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a Novel and Potent Vascular Endothelial Growth Factor Receptor Inhibitor

Philip A. Harris, Amogh Boloor, Mui Cheung, +18

Journal of Medicinal Chemistry

An Orally Active TRPV4 Channel Blocker Prevents and Resolves Pulmonary Edema Induced by Heart Failure

Kevin S. Thorneloe, Mui Cheung, Weike Bao, +33

Science Translational Medicine

2,4-Dinitrobenzenesulfonamides: A simple and practical method for the preparation of a variety of secondary amines and diamines

Tohru Fukuyama, Mui Cheung, Chung-Kuang Jow, +2

Tetrahedron Letters

Chemical EngineeringEngineeringOrganic ChemistryPractical MethodStereoselective Synthesis +3

Discovery of Novel Benzimidazoles as Potent Inhibitors of TIE-2 and VEGFR-2 Tyrosine Kinase Receptors

Masaichi Hasegawa, Naohiko Nishigaki, Yoshiaki Washio, +11

Journal of Medicinal Chemistry

Drug TargetBioorganic ChemistryMolecular BiologyPharmacotherapyChemical Biology +17

TRPV4 inhibition counteracts edema and inflammation and improves pulmonary function and oxygen saturation in chemically induced acute lung injury

Shrilatha Balakrishna, Weifeng Song, Satyanarayana Achanta, +14

American Journal of Physiology-Lung Cellular and Molecular Physiology

Acute Lung InjuryAsthmaInflammatory Lung DiseaseLung InflammationImmunology +17

<i>In vitro</i> biological activity of a novel small-molecule inhibitor of polo-like kinase 1

Timothy J. Lansing, Randy T. McConnell, Derek R. Duckett, +9

Molecular Cancer Therapeutics

Discovery and Evaluation of 2-Anilino-5-aryloxazoles as a Novel Class of VEGFR2 Kinase Inhibitors

Philip A. Harris, Mui Cheung, R. Hunter, +11

Journal of Medicinal Chemistry

Discovery of GSK2193874: An Orally Active, Potent, and Selective Blocker of Transient Receptor Potential Vanilloid 4

Mui Cheung, Weike Bao, David J. Behm, +13

ACS Medicinal Chemistry Letters

Pyrazolo[1,5-a]pyridines as p38 Kinase Inhibitors

Kirk L. Stevens, David Jung, Michael J. Alberti, +7

Organic Letters

Medicinal ChemistryHeterocyclicP38 Kinase InhibitorsBiochemistryMedicine +12