Hidehisa Iwata

A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells

Masahiro Wakita, Akiko Takahashi, Osamu Sano et al. · Nature Communications · 2020 · 201 citations · Full text

Life Sciences, Molecular Biology, Oncology +15

Structure of the Bacillus subtilis quorum-sensing peptide pheromone ComX

Masahiro Okada, Isao Satō, Soo‐Jeong Cho et al. · Nature Chemical Biology · 2005 · 185 citations

Life Sciences, Biochemistry, Microbiology +14

Structure-Based Approach for the Discovery of Pyrrolo[3,2-<i>d</i>]pyrimidine-Based EGFR T790M/L858R Mutant Inhibitors

Satoshi Sogabe, Youichi Kawakita, S. Igaki et al. · ACS Medicinal Chemistry Letters · 2012 · 167 citations · Full text

Medicine, Oncology, Pharmacology +13

Design, synthesis, and evaluation of 5-methyl-4-phenoxy-5H-pyrrolo[3,2-d]pyrimidine derivatives: Novel VEGFR2 kinase inhibitors binding to inactive kinase conformation

Yuya Oguro, Naoki Miyamoto, Kengo Okada et al. · Bioorganic & Medicinal Chemistry · 2010 · 122 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Design and synthesis of novel pyrimido[4,5-b]azepine derivatives as HER2/EGFR dual inhibitors

Youichi Kawakita, Masaki Seto, Tomohiro Ohashi et al. · Bioorganic & Medicinal Chemistry · 2013 · 76 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12