S. Igaki

Structure-Based Approach for the Discovery of Pyrrolo[3,2-<i>d</i>]pyrimidine-Based EGFR T790M/L858R Mutant Inhibitors

Satoshi Sogabe, Youichi Kawakita, S. Igaki et al. · ACS Medicinal Chemistry Letters · 2012 · 161 citations · Full text

Molecular Biology, Egfr Inhibitors, Chemical Biology +19

Discovery of Potent Mcl-1/Bcl-xL Dual Inhibitors by Using a Hybridization Strategy Based on Structural Analysis of Target Proteins

Yuta Tanaka, Katsuji Aikawa, Goushi Nishida et al. · Journal of Medicinal Chemistry · 2013 · 108 citations · Full text

Cryo-EM Structure of K+-Bound hERG Channel Complexed with the Blocker Astemizole

Tatsuki Asai, Naruhiko Adachi, Toshio Moriya et al. · Structure · 2021 · 93 citations

Engineering, Physics, Cryogenics +6

Newly identified genes involved in the signal transduction of Escherichia coli K-12

Ryutaro Utsumi, Satoshi Katayama, Manabu Taniguchi et al. · Gene · 1994 · 81 citations

Signal Transduction, Protein Expression, Natural Sciences +8

T-448, a specific inhibitor of LSD1 enzyme activity, improves learning function without causing thrombocytopenia in mice

Satoru Matsuda, Rina Baba, Hideyuki Oki et al. · Neuropsychopharmacology · 2018 · 45 citations · Full text

Specific Inhibitor, Medicine, Immunology +4