Rina Baba

T-448, a specific inhibitor of LSD1 enzyme activity, improves learning function without causing thrombocytopenia in mice

Satoru Matsuda, Rina Baba, Hideyuki Oki et al. · Neuropsychopharmacology · 2018 · 45 citations · Full text

Specific Inhibitor, Medicine, Immunology +4

Inhibition of KDM1A activity restores adult neurogenesis and improves hippocampal memory in a mouse model of Kabuki syndrome

Li Zhang, Genay Pilarowski, Emilio Merlo Pich et al. · Molecular Therapy — Methods & Clinical Development · 2021 · 42 citations · Full text

LSD1 enzyme inhibitor TAK-418 unlocks aberrant epigenetic machinery and improves autism symptoms in neurodevelopmental disorder models

Rina Baba, Satoru Matsuda, Yuuichi Arakawa et al. · Science Advances · 2021 · 36 citations · Full text

Design, synthesis, and structure–activity relationship of TAK-418 and its derivatives as a novel series of LSD1 inhibitors with lowered risk of hematological side effects

Yasushi Hattori, Shigemitsu Matsumoto, Shinji Morimoto et al. · European Journal of Medicinal Chemistry · 2022 · 17 citations · Full text

Structure–activity Relationship, Drug Target, Pharmacotherapy +17

Investigating the Therapeutic Potential of LSD1 Enzyme Activity-Specific Inhibition by TAK-418 for Social and Memory Deficits in Rodent Disease Models

Rina Baba, Satoru Matsuda, Ryota Maeda et al. · ACS Chemical Neuroscience · 2022 · 14 citations · Full text

Therapeutic Potential, Epigenetic Change, Neurochemical Biomarkers +20