Hideyuki Oki

Crystal structure of methionine aminopeptidase from hyperthermophile, Pyrococcus furiosus

T.H. Tahirov, Hideyuki Oki, Tomitake Tsukihara et al. · Journal of Molecular Biology · 1998 · 144 citations

Crystal Structure, Biochemistry, Enzyme Catalysis +3

Cryo-EM Structure of K+-Bound hERG Channel Complexed with the Blocker Astemizole

Tatsuki Asai, Naruhiko Adachi, Toshio Moriya et al. · Structure · 2021 · 93 citations

Engineering, Physics, Cryogenics +6

Design and Synthesis of Novel DFG-Out RAF/Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) Inhibitors. 1. Exploration of [5,6]-Fused Bicyclic Scaffolds

Masanori Okaniwa, Masaaki Hirose, Takashi Imada et al. · Journal of Medicinal Chemistry · 2012 · 76 citations

Discovery of N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-methylphenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide (TAK-593), a highly potent VEGFR2 kinase inhibitor

Naoki Miyamoto, Nozomu Sakai, Takaharu Hirayama et al. · Bioorganic & Medicinal Chemistry · 2013 · 70 citations · Full text

Discovery of 1-[2-Fluoro-4-(1<i>H</i>-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1<i>H</i>-pyrazol-5-yl)pyridazin-4(1<i>H</i>)-one (TAK-063), a Highly Potent, Selective, and Orally Active Phosphodiesterase 10A (PDE10A) Inhibitor

Jun Kunitomo, Masato Yoshikawa, Makoto Fushimi et al. · Journal of Medicinal Chemistry · 2014 · 64 citations

Pharmaceutical Science, Pharmacotherapy, Pharmaceutical Chemistry +19