Jun Kunitomo

2-{3-[4-(Alkylsulfinyl)phenyl]-1-benzofuran-5-yl}-5-methyl-1,3,4-oxadiazole Derivatives as Novel Inhibitors of Glycogen Synthase Kinase-3β with Good Brain Permeability

Morihisa Saitoh, Jun Kunitomo, Eiji Kimura et al. · Journal of Medicinal Chemistry · 2009 · 122 citations · Full text

-5-Methyl-1,3,4-oxadiazole Derivatives, Good Brain Permeability, Pharmacotherapy +19

Design, synthesis and structure–activity relationships of 1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3β

Morihisa Saitoh, Jun Kunitomo, Eiji Kimura et al. · Bioorganic & Medicinal Chemistry · 2009 · 106 citations · Full text

Medicinal Chemistry, Biochemistry, Natural Sciences +10

A novel glycogen synthase kinase‐3 inhibitor 2‐methyl‐5‐(3‐{4‐[(<i>S </i>)‐methylsulfinyl]phenyl}‐1‐benzofuran‐5‐yl)‐1,3,4‐oxadiazole decreases tau phosphorylation and ameliorates cognitive deficits in a transgenic model of Alzheimer’s disease

Tomohiro Onishi, Hiroki Iwashita, Yumiko Uno et al. · Journal of Neurochemistry · 2011 · 89 citations · Full text

Amyloid β, Brain Penetration, Neurochemical Biomarkers +28

Discovery of 1-[2-Fluoro-4-(1<i>H</i>-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1<i>H</i>-pyrazol-5-yl)pyridazin-4(1<i>H</i>)-one (TAK-063), a Highly Potent, Selective, and Orally Active Phosphodiesterase 10A (PDE10A) Inhibitor

Jun Kunitomo, Masato Yoshikawa, Makoto Fushimi et al. · Journal of Medicinal Chemistry · 2014 · 64 citations

Pharmaceutical Science, Pharmacotherapy, Pharmaceutical Chemistry +19

Atropisomeric Flavoenzyme Models with a Modified Pyrimidine Ring:  Syntheses, Physical Properties, and Stereochemistry in the Reactions with NAD(P)H Analogs

Atsuyoshi Ohno, Jun Kunitomo, Yasushi Kawai et al. · The Journal of Organic Chemistry · 1996 · 31 citations

Bioorganic Chemistry, Organic Chemistry, Modified Pyrimidine Ring +17