Jun Kunitomo

2-{3-[4-(Alkylsulfinyl)phenyl]-1-benzofuran-5-yl}-5-methyl-1,3,4-oxadiazole Derivatives as Novel Inhibitors of Glycogen Synthase Kinase-3β with Good Brain Permeability

Morihisa Saitoh, Jun Kunitomo, Eiji Kimura et al. · Journal of Medicinal Chemistry · 2009 · 125 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +10

Design, synthesis and structure–activity relationships of 1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3β

Morihisa Saitoh, Jun Kunitomo, Eiji Kimura et al. · Bioorganic & Medicinal Chemistry · 2009 · 107 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

A novel glycogen synthase kinase‐3 inhibitor 2‐methyl‐5‐(3‐{4‐[(<i>S </i>)‐methylsulfinyl]phenyl}‐1‐benzofuran‐5‐yl)‐1,3,4‐oxadiazole decreases tau phosphorylation and ameliorates cognitive deficits in a transgenic model of Alzheimer’s disease

Tomohiro Onishi, Hiroki Iwashita, Yumiko Uno et al. · Journal of Neurochemistry · 2011 · 89 citations · Full text

Life Sciences, Neuroscience, Pharmacology +17

Discovery of 1-[2-Fluoro-4-(1<i>H</i>-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1<i>H</i>-pyrazol-5-yl)pyridazin-4(1<i>H</i>)-one (TAK-063), a Highly Potent, Selective, and Orally Active Phosphodiesterase 10A (PDE10A) Inhibitor

Jun Kunitomo, Masato Yoshikawa, Makoto Fushimi et al. · Journal of Medicinal Chemistry · 2014 · 65 citations

Pharmacy, Medicinal Chemistry, Pharmacology +15

Design and synthesis of a novel 2-oxindole scaffold as a highly potent and brain-penetrant phosphodiesterase 10A inhibitor

Masato Yoshikawa, Haruhi Kamisaki, Jun Kunitomo et al. · Bioorganic & Medicinal Chemistry · 2015 · 32 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +10