Role of gob-5 in mucus overproduction and airway hyperresponsiveness in asthma

Atsushi Nakanishi, Shigeru Morita, Hiroki Iwashita, +6

Proceedings of the National Academy of Sciences

AsthmaInflammatory Lung DiseaseLung InflammationAllergy MedicineImmunology +16

Increased Expression of the Human Ca ^{2 +} -activated Cl ⁻ Channel 1 (CaCC1) Gene in the Asthmatic Airway

Makoto Hoshino, Shigeru Morita, Hiroki Iwashita, +7

American Journal of Respiratory and Critical Care Medicine

2-{3-[4-(Alkylsulfinyl)phenyl]-1-benzofuran-5-yl}-5-methyl-1,3,4-oxadiazole Derivatives as Novel Inhibitors of Glycogen Synthase Kinase-3β with Good Brain Permeability

Morihisa Saitoh, Jun Kunitomo, Eiji Kimura, +13

Journal of Medicinal Chemistry

-5-Methyl-1,3,4-oxadiazole DerivativesGood Brain PermeabilityPharmacotherapyPharmaceutical ChemistrySocial Sciences +17

A novel glycogen synthase kinase‐3 inhibitor 2‐methyl‐5‐(3‐{4‐[(<i>S </i>)‐methylsulfinyl]phenyl}‐1‐benzofuran‐5‐yl)‐1,3,4‐oxadiazole decreases tau phosphorylation and ameliorates cognitive deficits in a transgenic model of Alzheimer’s disease

Tomohiro Onishi, Hiroki Iwashita, Yumiko Uno, +7

Journal of Neurochemistry

Amyloid βBrain PenetrationNeurochemical BiomarkersSynaptic SignalingSocial Sciences +26

Discovery of an Orally Bioavailable, Brain-Penetrating, in Vivo Active Phosphodiesterase 2A Inhibitor Lead Series for the Treatment of Cognitive Disorders

Satoshi Mikami, Shigekazu Sasaki, Yasutomi Asano, +8

Journal of Medicinal Chemistry

Drug TargetLead IdentificationNeurochemical BiomarkersCognitive DisordersChemical Biology +18

Discovery of Clinical Candidate <i>N</i>-((1<i>S</i>)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-<i>b</i>]pyrazine-4(1<i>H</i>)-carboxamide (TAK-915): A Highly Potent, Selective, and Brain-Penetrating Phosphodiesterase 2A Inhibitor for the Treatment of Cognitive Disorders

Satoshi Mikami, Shinji Nakamura, Tomoko Ashizawa, +14

Journal of Medicinal Chemistry

Brain-penetrating Phosphodiesterase 2ABrain PenetrationPharmacotherapyCognitive DisordersPharmaceutical Chemistry +15

Efficacy of a novel, orally active GSK-3 inhibitor 6-Methyl-N-[3-[[3-(1-methylethoxy)propyl]carbamoyl]-1H-pyrazol-4-yl]pyridine-3-carboxamide in tau transgenic mice

Yumiko Uno, Hiroki Iwashita, Tetsuya Tsukamoto, +4

Brain Research

Medicinal ChemistryMedicineImmunologyPharmacological AgentExperimental Therapeutic +3

Phosphodiesterase 2A Inhibitor TAK-915 Ameliorates Cognitive Impairments and Social Withdrawal in N-Methyl-d-Aspartate Receptor Antagonist–Induced Rat Models of Schizophrenia

Masato Nakashima, Haruka Imada, Eri Shiraishi, +5

Journal of Pharmacology and Experimental Therapeutics

Role of Eosinophil Chemotactic Factor by T Lymphocytes on Airway Hyperresponsiveness in a Murine Model of Allergic Asthma

Hiroki Iwashita, Shigeru Morita, Yoji Sagiya, +1

American Journal of Respiratory Cell and Molecular Biology

AsthmaMolecular ImmunologyAllergyInflammatory Lung DiseaseLung Inflammation +13

PDE2A Inhibition Enhances Axonal Sprouting, Functional Connectivity, and Recovery after Stroke

Kirollos Bechay, Nora Abduljawad, Shahrzad Latifi, +3

Journal of Neuroscience