Hiroki Iwashita

Role of gob-5 in mucus overproduction and airway hyperresponsiveness in asthma

Atsushi Nakanishi, Shigeru Morita, Hiroki Iwashita et al. · Proceedings of the National Academy of Sciences · 2001 · 289 citations · Full text

Asthma, Inflammatory Lung Disease, Lung Inflammation +18

Increased Expression of the Human Ca ^{2 +} -activated Cl ⁻ Channel 1 (CaCC1) Gene in the Asthmatic Airway

Makoto Hoshino, Shigeru Morita, Hiroki Iwashita et al. · American Journal of Respiratory and Critical Care Medicine · 2002 · 133 citations

2-{3-[4-(Alkylsulfinyl)phenyl]-1-benzofuran-5-yl}-5-methyl-1,3,4-oxadiazole Derivatives as Novel Inhibitors of Glycogen Synthase Kinase-3β with Good Brain Permeability

Morihisa Saitoh, Jun Kunitomo, Eiji Kimura et al. · Journal of Medicinal Chemistry · 2009 · 122 citations · Full text

-5-Methyl-1,3,4-oxadiazole Derivatives, Good Brain Permeability, Pharmacotherapy +19

A novel glycogen synthase kinase‐3 inhibitor 2‐methyl‐5‐(3‐{4‐[(<i>S </i>)‐methylsulfinyl]phenyl}‐1‐benzofuran‐5‐yl)‐1,3,4‐oxadiazole decreases tau phosphorylation and ameliorates cognitive deficits in a transgenic model of Alzheimer’s disease

Tomohiro Onishi, Hiroki Iwashita, Yumiko Uno et al. · Journal of Neurochemistry · 2011 · 89 citations · Full text

Amyloid β, Brain Penetration, Neurochemical Biomarkers +28

Discovery of an Orally Bioavailable, Brain-Penetrating, in Vivo Active Phosphodiesterase 2A Inhibitor Lead Series for the Treatment of Cognitive Disorders

Satoshi Mikami, Shigekazu Sasaki, Yasutomi Asano et al. · Journal of Medicinal Chemistry · 2017 · 41 citations · Full text

Drug Target, Lead Identification, Neurochemical Biomarkers +20