Morihisa Saitoh

2-{3-[4-(Alkylsulfinyl)phenyl]-1-benzofuran-5-yl}-5-methyl-1,3,4-oxadiazole Derivatives as Novel Inhibitors of Glycogen Synthase Kinase-3β with Good Brain Permeability

Morihisa Saitoh, Jun Kunitomo, Eiji Kimura et al. · Journal of Medicinal Chemistry · 2009 · 122 citations · Full text

-5-Methyl-1,3,4-oxadiazole Derivatives, Good Brain Permeability, Pharmacotherapy +19

Discovery of 7-Oxo-2,4,5,7-tetrahydro-6 <i>H</i> -pyrazolo[3,4- <i>c</i> ]pyridine Derivatives as Potent, Orally Available, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure–Kinetic Relationships

Masato Yoshikawa, Morihisa Saitoh, Taisuke Katoh et al. · Journal of Medicinal Chemistry · 2018 · 115 citations · Full text

Design, synthesis and structure–activity relationships of 1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3β

Morihisa Saitoh, Jun Kunitomo, Eiji Kimura et al. · Bioorganic & Medicinal Chemistry · 2009 · 106 citations · Full text

Medicinal Chemistry, Biochemistry, Natural Sciences +10

A novel glycogen synthase kinase‐3 inhibitor 2‐methyl‐5‐(3‐{4‐[(<i>S </i>)‐methylsulfinyl]phenyl}‐1‐benzofuran‐5‐yl)‐1,3,4‐oxadiazole decreases tau phosphorylation and ameliorates cognitive deficits in a transgenic model of Alzheimer’s disease

Tomohiro Onishi, Hiroki Iwashita, Yumiko Uno et al. · Journal of Neurochemistry · 2011 · 89 citations · Full text

Amyloid β, Brain Penetration, Neurochemical Biomarkers +28

Fragment-based drug discovery of potent and selective MKK3/6 inhibitors

Mark E. Adams, Toshitake Kobayashi, J. David Lawson et al. · Bioorganic & Medicinal Chemistry Letters · 2015 · 29 citations · Full text

Medicinal Chemistry, Fragment-based Drug Discovery, Drug Target +4