Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress

F. Michael Yakes, Bennett Van Houten

Proceedings of the National Academy of Sciences

Cabozantinib (XL184), a Novel MET and VEGFR2 Inhibitor, Simultaneously Suppresses Metastasis, Angiogenesis, and Tumor Growth

F. Michael Yakes, Jason Chen, Jenny Tan, +14

Molecular Cancer Therapeutics

AngiogenesisNovel MetMedicineTumor GrowthVegfr Signaling +11

PKB/Akt mediates cell-cycle progression by phosphorylation of p27Kip1 at threonine 157 and modulation of its cellular localization

Incheol Shin, F. Michael Yakes, Federico Rojo, +4

Nature Medicine

Signal TransductionSignaling PathwayCell DivisionCell RegulationNatural Sciences +12

Herceptin-induced inhibition of phosphatidylinositol-3 kinase and Akt Is required for antibody-mediated effects on p27, cyclin D1, and antitumor action.

F. Michael Yakes, Wichai Chinratanalab, Christoph A. Ritter, +3

PubMed

Cyclin D1ImmunologyHer2 Gene AmplificationImmunologic MechanismImmunotherapy +18

Epidermal growth factor receptor (HER1) tyrosine kinase inhibitor ZD1839 (Iressa) inhibits HER2/neu (erbB2)-overexpressing breast cancer cells in vitro and in vivo.

Stacy L. Moulder, F. Michael Yakes, Senthil K. Muthuswamy, +3

PubMed

Breast OncologyMedicineReceptor Tyrosine KinaseBreast Cancer CellsPharmacology +13

Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors

Roberto Bianco, Incheol Shin, Christoph A. Ritter, +7

Oncogene

MedicineReceptor Tyrosine KinasePharmacologyAntitumor ActionTumor Suppressor +3

Hydrogen Peroxide– and Peroxynitrite-Induced Mitochondrial DNA Damage and Dysfunction in Vascular Endothelial and Smooth Muscle Cells

Scott W. Ballinger, Cam Patterson, Chang-Ning Yan, +8

Circulation Research

Targeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein Homeostasis

Daniel J. Anderson, Ronan Le Moigne, Stevan Djakovic, +20

Cancer Cell

Protein FunctionMedicineNatural SciencesProteomicsMolecular Biology +11

Inhibition of Tumor Cell Growth, Invasion, and Metastasis by EXEL-2880 (XL880, GSK1363089), a Novel Inhibitor of HGF and VEGF Receptor Tyrosine Kinases

Fawn Qian, Stefan Engst, Peiwen Yu, +14

Cancer Research

Tumor Cell GrowthNovel InhibitorVegf Receptor 2Tumor BiologyAngiogenesis +14

Discovery of a First-in-Class, Potent, Selective, and Orally Bioavailable Inhibitor of the p97 AAA ATPase (CB-5083)

Han-Jie Zhou, Jinhai Wang, Bing Yao, +17

Journal of Medicinal Chemistry

ApoptosisCell DeathProtein HomeostasisTumor BiologyMedicinal Chemistry +18