PKB/Akt mediates cell-cycle progression by phosphorylation of p27Kip1 at threonine 157 and modulation of its cellular localization

Incheol Shin, F. Michael Yakes, Federico Rojo, +4

Nature Medicine

Signal TransductionSignaling PathwayCell DivisionCell RegulationNatural Sciences +12

Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors

Roberto Bianco, Incheol Shin, Christoph A. Ritter, +7

Oncogene

MedicineReceptor Tyrosine KinasePharmacologyAntitumor ActionTumor Suppressor +3

Type I Transforming Growth Factor β Receptor Binds to and Activates Phosphatidylinositol 3-Kinase

Jae Youn Yi, Incheol Shin, Carlos L. Arteaga

Journal of Biological Chemistry

Activates PhosphatidylinositolIi Tgfbeta ReceptorsImmunologyCell GrowthCellular Physiology +14

Transforming Growth Factor β Enhances Epithelial Cell Survival via Akt-dependent Regulation of FKHRL1

Incheol Shin, Andrei V. Bakin, Ulrich Rodeck, +2

Molecular Biology of the Cell

Activated type I TGFβ receptor kinase enhances the survival of mammary epithelial cells and accelerates tumor progression

Rebecca S. Muraoka-Cook, Incheol Shin, Jae Youn Yi, +5

Oncogene

Tumor BiologyTgfβ Receptor KinaseMedicineMammary Epithelial CellsActivated Type +10

Glut1 promotes cell proliferation, migration and invasion by regulating epidermal growth factor receptor and integrin signaling in triple-negative breast cancer cells

Sunhwa Oh, Hyungjoo Kim, KeeSoo Nam, +1

BMB Reports

Cell ProliferationCancer BiologyTumor BiologyCancer Cell BiologyMetabolic Signaling +14

The alkaloid Berberine inhibits the growth of Anoikis-resistant MCF-7 and MDA-MB-231 breast cancer cell lines by inducing cell cycle arrest

J.B. Kim, Jinha Yu, Ellen Wen-Ching Ko, +6

Phytomedicine

Tumor BiologyMedicinePharmacologyAnoikis-resistant Mcf-7Cell Cycle Arrest +7

Reduction of Cytosolic p27Kip1 Inhibits Cancer Cell Motility, Survival, and Tumorigenicity

Frederick Y. Wu, Shizhen Emily Wang, Melinda E. Sanders, +4

Cancer Research

Tumor BiologyCytosolic P27P27-expressing TumorsCell RegulationGlioma +11

CD44 regulates cell proliferation, migration, and invasion via modulation of c-Src transcription in human breast cancer cells

KeeSoo Nam, Sunhwa Oh, Kyung‐min Lee, +2

Cellular Signalling

HER2/Neu (ErbB2) Signaling to Rac1-Pak1 Is Temporally and Spatially Modulated by Transforming Growth Factor β

Shizhen Emily Wang, Incheol Shin, Frederick Y. Wu, +2

Cancer Research