A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer’s disease

Sara Mostafavi, Chris Gaiteri, Sarah E. Sullivan, +18

Nature Neuroscience

Neurodegenerative DiseasesAlzheimer's DiseaseAgingMolecular NeuroscienceMedicine +9

Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regions

Solveig K. Sieberts, Thanneer M. Perumal, Minerva M. Carrasquillo, +182

Scientific Data

Multi-omics monitoring of drug response in rheumatoid arthritis in pursuit of molecular remission

Shinya Tasaki, Katsuya Suzuki, Yoshiaki Kassai, +16

Nature Communications

Stem cell-derived neurons reflect features of protein networks, neuropathology, and cognitive outcome of their aged human donors

Valentina N. Lagomarsino, Richard V. Pearse, Lei Liu, +32

Neuron

Neurodegenerative DiseasesHuman DonorsStem Cell-derived NeuronsProtein NetworksMedicine +9

CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor

Tyler Funnell, Shinya Tasaki, Arusha Oloumi, +33

Nature Communications

Cortical Proteins Associated With Cognitive Resilience in Community-Dwelling Older Persons

Lei Yu, Shinya Tasaki, Julie A. Schneider, +10

JAMA Psychiatry

Benchmarking of deep neural networks for predicting personal gene expression from DNA sequence highlights shortcomings

Alexander Sasse, Bernard Ng, Anna Spiro, +6

Nature Genetics

Deep Neural NetworksFunctional GenomicsMachine LearningSystems BiologyEngineering +10

Multiomic disease signatures converge to cytotoxic CD8 T cells in primary Sjögren's syndrome

Shinya Tasaki, Katsuya Suzuki, Ayumi Nishikawa, +15

Annals of the Rheumatic Diseases

Sleep fragmentation, microglial aging, and cognitive impairment in adults with and without Alzheimer’s dementia

Kirusanthy Kaneshwaran, Marta Olah, Shinya Tasaki, +7

Science Advances

Sleep DisordersAgingImmunologyAlzheimer ’Sleep Fragmentation +18

Inferring protein expression changes from mRNA in Alzheimer’s dementia using deep neural networks

Shinya Tasaki, Jishu Xu, Denis Avey, +6

Nature Communications