R.J. Skene

Structural Snapshots of Human HDAC8 Provide Insights into the Class I Histone Deacetylases

John R. Somoza, R.J. Skene, B.A. Katz et al. · Structure · 2004 · 691 citations · Full text

Histone Modifications, Chromatin, Structural Snapshots +13

Structural Basis for the Autoinhibition and STI-571 Inhibition of c-Kit Tyrosine Kinase

Clifford D. Mol, Douglas R. Dougan, T. Schneider et al. · Journal of Biological Chemistry · 2004 · 614 citations · Full text

Structural Analysis of the Mechanism of Inhibition and Allosteric Activation of the Kinase Domain of HER2 Protein

Kathleen Aertgeerts, R.J. Skene, Jason K. Yano et al. · Journal of Biological Chemistry · 2011 · 414 citations · Full text

Crystal Structure, Molecular Biology, Cancer Biology +22

Discovery of Alogliptin:  A Potent, Selective, Bioavailable, and Efficacious Inhibitor of Dipeptidyl Peptidase IV

Jun Feng, Zhiyuan Zhang, Michael B. Wallace et al. · Journal of Medicinal Chemistry · 2007 · 399 citations · Full text

Plasma Dpp-4 Activity, Pharmacotherapy, Chemical Biology +17

Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides

Jerome C. Bressi, Andy Jennings, R.J. Skene et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 249 citations · Full text

Combinatorial Chemistry, Medicinal Chemistry, Natural Sciences +4