R.J. Skene

Structural Snapshots of Human HDAC8 Provide Insights into the Class I Histone Deacetylases

John R. Somoza, R.J. Skene, B.A. Katz et al. · Structure · 2004 · 698 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +9

Structural Basis for the Autoinhibition and STI-571 Inhibition of c-Kit Tyrosine Kinase

Clifford D. Mol, Douglas R. Dougan, T. Schneider et al. · Journal of Biological Chemistry · 2004 · 624 citations · Full text

Life Sciences, Molecular Biology, Oncology +17

Structural Analysis of the Mechanism of Inhibition and Allosteric Activation of the Kinase Domain of HER2 Protein

Kathleen Aertgeerts, R.J. Skene, Jason K. Yano et al. · Journal of Biological Chemistry · 2011 · 431 citations · Full text

Life Sciences, Molecular Biology, Oncology +17

Discovery of Alogliptin:  A Potent, Selective, Bioavailable, and Efficacious Inhibitor of Dipeptidyl Peptidase IV

Jun Feng, Zhiyuan Zhang, Michael B. Wallace et al. · Journal of Medicinal Chemistry · 2007 · 404 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +6

Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides

Jerome C. Bressi, Andy Jennings, R.J. Skene et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 254 citations · Full text

Pharmacy, Chemistry, Medicinal Chemistry +9