Andy Jennings

Structural Snapshots of Human HDAC8 Provide Insights into the Class I Histone Deacetylases

John R. Somoza, R.J. Skene, B.A. Katz et al. · Structure · 2004 · 691 citations · Full text

Histone Modifications, Chromatin, Structural Snapshots +13

Structural Analysis of the Mechanism of Inhibition and Allosteric Activation of the Kinase Domain of HER2 Protein

Kathleen Aertgeerts, R.J. Skene, Jason K. Yano et al. · Journal of Biological Chemistry · 2011 · 414 citations · Full text

Crystal Structure, Molecular Biology, Cancer Biology +22

High-resolution structure of the human GPR40 receptor bound to allosteric agonist TAK-875

Ankita Srivastava, Jason K. Yano, Yoshihiko Hirozane et al. · Nature · 2014 · 342 citations

Molecular Pharmacology, Drug Target, Signal Transduction +11

Structural and Kinetic Analysis of the Substrate Specificity of Human Fibroblast Activation Protein α

Kathleen Aertgeerts, Irena Levin, Lihong Shi et al. · Journal of Biological Chemistry · 2005 · 276 citations · Full text

Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression

Lodoe Lama, Carolina Adura, Wei Xie et al. · Nature Communications · 2019 · 269 citations · Full text