Lodoe Lama

Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice

Jessica Vincent, Carolina Adura, Pu Gao et al. · Nature Communications · 2017 · 360 citations · Full text

Primary Macrophages, Innate Immune System, Immunology +21

Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression

Lodoe Lama, Carolina Adura, Wei Xie et al. · Nature Communications · 2019 · 269 citations · Full text

Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation

Wei Xie, Lodoe Lama, Carolina Adura et al. · Proceedings of the National Academy of Sciences · 2019 · 192 citations · Full text

Circularized synthetic oligodeoxynucleotides serve as promoterless RNA polymerase III templates for small RNA generation in human cells

Christine Seidl, Lodoe Lama, Kevin Ryan · Nucleic Acids Research · 2012 · 26 citations · Full text

Engineering, Molecular Biology, Synthetic Rna Formulations +18

Small RNA-seq: The RNA 5’-end adapter ligation problem and how to circumvent it

Lodoe Lama, J. Cobo, Diego F. Buenaventura et al. · Journal of Biological Methods · 2019 · 20 citations · Full text