Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice

Jessica Vincent, Carolina Adura, Pu Gao, +15

Nature Communications

Primary MacrophagesInnate Immune SystemImmunologyImmune RegulationImmunologic Mechanism +19

Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression

Lodoe Lama, Carolina Adura, Wei Xie, +21

Nature Communications

Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation

Wei Xie, Lodoe Lama, Carolina Adura, +4

Proceedings of the National Academy of Sciences

Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia

Gerard Minuesa, Steven K. Albanese, Wei Xie, +29

Nature Communications

Tumor BiologySystems BiologyNatural SciencesRna Binding ProteinsAcute Myeloid Leukemia +13

Improving The Brain Delivery of Gold Nanoparticles by Conjugation with An Amphipathic Peptide

Simón Guerrero, Eyleen Araya, Jenny L. Fiedler, +7

Nanomedicine

Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase

Lavoisier Ramos‐Espiritu, S. Kleinboelting, Felipe Navarrete, +13

Nature Chemical Biology

Molecular PharmacologyBiochemistryMedicineNatural SciencesEnzyme Catalysis +7

Stable Conjugates of Peptides with Gold Nanorods for Biomedical Applications with Reduced Effects on Cell Viability

Carolina Adura, Simón Guerrero, Edison Salas‐Huenuleo, +7

ACS Applied Materials & Interfaces

Reconstitution of a <i>Mycobacterium tuberculosis</i> proteostasis network highlights essential cofactor interactions with chaperone DnaK

Tania J. Lupoli, Allison Fay, Carolina Adura, +2

Proceedings of the National Academy of Sciences

An allosteric inhibitor of bacterial Hsp70 chaperone potentiates antibiotics and mitigates resistance

Jordan Hosfelt, Aweon Richards, Meng Zheng, +8

Cell chemical biology

Bacterial Hsp70 ChaperoneMitigates ResistanceAntibioticsAntimicrobial SusceptibilityMedicine +10

&lt;p&gt;Improving Cell Penetration of Gold Nanorods by Using an Amphipathic Arginine Rich Peptide&lt;/p&gt;

Ana Riveros, Cynthia Eggeling, Sebastián Riquelme, +10

International Journal of Nanomedicine