Pu Gao

Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

Pu Gao, Manuel Ascano, Yang Wu et al. · Cell · 2013 · 1K citations · Full text

Natural Sciences, Biosynthesis, Molecular Biology +1

Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA

Pu Gao, Manuel Ascano, Thomas Zillinger et al. · Cell · 2013 · 560 citations · Full text

Sting Activation, Antiviral Dmxaa, Antiviral Drug Development +7

Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice

Jessica Vincent, Carolina Adura, Pu Gao et al. · Nature Communications · 2017 · 360 citations · Full text

Primary Macrophages, Innate Immune System, Immunology +21

PAM-Dependent Target DNA Recognition and Cleavage by C2c1 CRISPR-Cas Endonuclease

Hui Yang, Pu Gao, Kanagalaghatta R. Rajashankar et al. · Cell · 2016 · 276 citations · Full text

Engineering, C2c1 Crispr-cas Endonuclease, Genetic Engineering +8

Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression

Lodoe Lama, Carolina Adura, Wei Xie et al. · Nature Communications · 2019 · 269 citations · Full text