Tri-Institutional Therapeutics Discovery Institute

Statistics

Publications

144

Citations

14.8K

Authors

Location

New York, United States

Also known as Tri-I TDI

Tri-Institutional Therapeutics Discovery Institute is a facility institution in New York, United States known for medicinal chemistry, pharmacology, and pharmacy.

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Top concepts

Medicinal ChemistryDrug DiscoveryPharmacologyPharmacyEnzyme InhibitionDrug DesignLife SciencesProteasome InhibitorsMedicineOncology

Publications

144

Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice

Jessica Vincent, Carolina Adura, Pu Gao et al. · Nature Communications · 2017 · 372 citations · Full text

Life Sciences, Immunology, Molecular Biology +17

Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression

Lodoe Lama, Carolina Adura, Wei Xie et al. · Nature Communications · 2019 · 283 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation

Wei Xie, Lodoe Lama, Carolina Adura et al. · Proceedings of the National Academy of Sciences · 2019 · 205 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

Small-molecule inhibition of Lats kinases may promote Yap-dependent proliferation in postmitotic mammalian tissues

Nathaniel R. Kastan, Ksenia Gnedeva, Theresa Alisch et al. · Nature Communications · 2021 · 188 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +14

Neuropeptide regulation of non-redundant ILC2 responses at barrier surfaces

Amy M. Tsou, Hiroshi Yano, Christopher N. Parkhurst et al. · Nature · 2022 · 131 citations · Full text

Life Sciences, Immunology, Neuroscience +16

1–5 of 144

Authors

IC
Ivo C. Lorenz
Tri-Institutional Therapeutics Discovery Institute, United States
76 publications · 1.8K citations
21
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JD
John D. Ginn
Tri-Institutional Therapeutics Discovery Institute, United States
44 publications · 770 citations
17
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RO
Rei Okamoto
Tri-Institutional Therapeutics Discovery Institute, United States
30 publications · 1.1K citations
14
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RH
Ryoma Hara
Tri-Institutional Therapeutics Discovery Institute, United States
28 publications · 909 citations
14
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TY
Takafumi Yukawa
Tri-Institutional Therapeutics Discovery Institute, United States
20 publications · 326 citations
10
h-index

1–5 of 15