Cancer Cell · 2013 · 124 citations · 28 references
MedicineMolecular BiologyOncologyMolecular OncologyOncogenesSignal TransductionEnzyme InhibitionOncogene ActivationOncogenic Signaling PathwaysProtein Kinase CascadesProto-oncogene ActivationReceptor Tyrosine Kinase OncogenesBraf V600 MutationsBraf V600e MutationExtracellular Signal-regulated Kinase PathwayKinase InhibitorsMapk SignalingMitogen-activated Protein Kinase SignalingProtein Kinase InhibitorsRaf Signaling
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Medicine, Oncology, Pharmacology +17
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Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation
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Medicine, Cancer Biology, Oncology +11
RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
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