Laura Tandeske

Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance

Ala M. Shaqra, Sarah N. Zvornicanin, Qiu Yu J. Huang et al. · Nature Communications · 2022 · 125 citations · Full text

Life Sciences, Infectious Diseases, Molecular Biology +17

RAF Inhibitors Activate the MAPK Pathway by Relieving Inhibitory Autophosphorylation

Matthew Holderfield, Hanne Merritt, John S.D. Chan et al. · Cancer Cell · 2013 · 124 citations · Full text

Medicine, Molecular Biology, Oncology +17

Hepatitis C virus polyprotein vaccine formulations capable of inducing broad antibody and cellular immune responses

Michael Vajdy, Mark Selby, Angelica Medina-Selby et al. · Journal of General Virology · 2006 · 49 citations

Veterinary Medicine, Immunology, Infectious Diseases +17

Design and Discovery of <i>N</i>-(2-Methyl-5′-morpholino-6′-((tetrahydro-2<i>H</i>-pyran-4-yl)oxy)-[3,3′-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers

Gisele Nishiguchi, Alice Rico, Huw R. Tanner et al. · Journal of Medicinal Chemistry · 2017 · 44 citations · Full text

Medicine, Medicinal Chemistry, Oncology +15

Design and Discovery of <i>N</i>-(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic

Savithri Ramurthy, Benjamin R. Taft, Robert J. Aversa et al. · Journal of Medicinal Chemistry · 2019 · 40 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17