Huw R. Tanner

Synthesis of the C-1−C-28 ABCD Unit of Spongistatin 1

Matthew J. Gaunt, Alan S. Jessiman, Paolo Orsini et al. · Organic Letters · 2003 · 85 citations

Enantioselective Synthesis, Engineering, Double Conjugate Addition +10

Total Synthesis of Spongistatin 1: A Synthetic Strategy Exploiting Its Latent Pseudo‐Symmetry

Matthew Ball, Matthew J. Gaunt, David Höök et al. · Angewandte Chemie International Edition · 2005 · 78 citations

Bioorganic Chemistry, Engineering, Molecular Biology +17

A Practical and Efficient Synthesis of the C-16−C-28 Spiroketal Fragment (CD) of the Spongistatins

Matthew J. Gaunt, David Höök, Huw R. Tanner et al. · Organic Letters · 2003 · 51 citations

Combinatorial Chemistry, Bioorganic Chemistry, Engineering +17

Design and Discovery of <i>N</i>-(2-Methyl-5′-morpholino-6′-((tetrahydro-2<i>H</i>-pyran-4-yl)oxy)-[3,3′-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers

Gisele Nishiguchi, Alice Rico, Huw R. Tanner et al. · Journal of Medicinal Chemistry · 2017 · 44 citations · Full text

Drug Target, Kras Mutant Tumors, Kinase Inhibitors +17

Design and Discovery of <i>N</i>-(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic

Savithri Ramurthy, Benjamin R. Taft, Robert J. Aversa et al. · Journal of Medicinal Chemistry · 2019 · 38 citations · Full text