Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation

Ramin Nazarian, Hubing Shi, Qi Wang, +13

Nature

N-ras UpregulationMedicineMelanomaImmunologyCell Biology +5

Dissecting the genomic complexity underlying medulloblastoma

David Jones, Natalie Jäger, Marcel Kool, +84

Nature

Genome Sequencing of Pediatric Medulloblastoma Links Catastrophic DNA Rearrangements with TP53 Mutations

Tobias Rausch, David Jones, Marc Zapatka, +48

Cell

Dna SequencingSomatic VariantTumor HeterogeneityGeneticsDna Replication +6

Identification of Regulatory Networks in HSCs and Their Immediate Progeny via Integrated Proteome, Transcriptome, and DNA Methylome Analysis

Nina Cabezas‐Wallscheid, Daniel Klimmeck, Jenny Hansson, +21

Cell stem cell

ChromatinIntegrated ProteomeDevelopmental BiologyEpigenetic ChangeGenetics +10

DNA methylation dynamics during B cell maturation underlie a continuum of disease phenotypes in chronic lymphocytic leukemia

Christopher C. Oakes, Marc Seifert, Yassen Assenov, +23

Nature Genetics

Hematological MalignancyChromatinChronic Lymphocytic LeukemiaEpigenetic ChangeGenetics +8

Genome-wide DNA-methylation landscape defines specialization of regulatory T cells in tissues

Michael Delacher, Charles D. Imbusch, Dieter Weichenhan, +14

Nature Immunology

ChromatinLineage PlasticityFunctional GenomicsMedicineGenetics +10

Differential sensitivity of melanoma cell lines with BRAF V600E mutation to the specific Raf inhibitor PLX4032

Jonas Nørskov Søndergaard, Ramin Nazarian, Qi Wang, +16

Journal of Translational Medicine

Cancer BiologyTumor BiologyCancer Cell BiologyMolecular DiagnosticsRadiation Oncology +17

Tagmentation-based whole-genome bisulfite sequencing

Qi Wang, Lei Gu, Andrew C. Adey, +9

Nature Protocols

Dna SequencingFunctional GenomicsSequencingMolecular BiologyMicrobiology +6

Maternal phthalate exposure promotes allergic airway inflammation over 2 generations through epigenetic modifications

Susanne Jahreis, Saskia Trump, Mario Bauer, +20

Journal of Allergy and Clinical Immunology

Environment‐induced epigenetic reprogramming in genomic regulatory elements in smoking mothers and their children

Tobias Bauer, Saskia Trump, Naveed Ishaque, +30

Molecular Systems Biology