Nature · 2010 · 2.2K citations · 17 references
MedicineCancer BiologyOncologyMolecular OncologyNeoplasiaOncogenesMelanocytic TumorsMelanoma PharmacotherapyRas Family OncogenesTherapeutic ResistanceTyrosine Kinase InhibitorsB-raf InhibitorsMelanoma ProgressionRaf Signaling
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Mutations of the BRAF gene in human cancer
Helen Davies, Graham R. Bignell, Charles Cox et al. · Nature · 2002 · 10.7K citations
Inhibition of Mutated, Activated BRAF in Metastatic Melanoma
Keith T. Flaherty, Igor Puzanov, Kevin B. Kim et al. · New England Journal of Medicine · 2010 · 3.5K citations
Medicine, Oncology, Pharmacology +17
Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma
Gideon Bollag, Peter Hirth, James Tsai et al. · Nature · 2010 · 1.8K citations
Medicine, Oncology, Pharmacology +14
RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
Poulikos I. Poulikakos, Chao Zhang, Gideon Bollag et al. · Nature · 2010 · 1.8K citations · Full text
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
Georgia Hatzivassiliou, Kyung Song, Ivana Yen et al. · Nature · 2010 · 1.6K citations
Medicine, Cancer Biology, Oncology +15