Concepedia

Braf V600 Mutations

Braf V600 Mutation is a specific oncogenic mutation in the BRAF gene characterized by a valine-to-glutamate substitution at codon 600, leading to constitutive activation of the MAPK signaling pathway and promoting tumorigenesis.

3.4K

Publications

310.8K

Citations

23.1K

Authors

3.7K

Institutions

Publications per year

2017–2026

1.5K

Parents

Publications

3.4K

Mutations of the BRAF gene in human cancer

Helen Davies, Graham R. Bignell, Charles Cox et al. · Nature · 2002 · 10.7K citations

, , +12

Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation

Paul B. Chapman, Axel Hauschild, Caroline Robert et al. · New England Journal of Medicine · 2011 · 7.7K citations · Full text

, , +9

Nivolumab in Previously Untreated Melanoma without <i>BRAF</i> Mutation

Caroline Robert, Georgina V. Long, Benjamin Brady et al. · New England Journal of Medicine · 2014 · 5.4K citations · Full text

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BAY 43-9006 Exhibits Broad Spectrum Oral Antitumor Activity and Targets the RAF/MEK/ERK Pathway and Receptor Tyrosine Kinases Involved in Tumor Progression and Angiogenesis

Scott M. Wilhelm, Christopher Carter, LiYa Tang et al. · Cancer Research · 2004 · 4K citations · Full text

, , +17

Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

Keith T. Flaherty, Igor Puzanov, Kevin B. Kim et al. · New England Journal of Medicine · 2010 · 3.5K citations

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1–5 of 3.4K

Authors

23.1K

  1. GV
    Georgina V. Long

    The University of Sydney, Australia

    73 publications · 25.2K citations

    46

    h-index

  2. KT
    Keith T. Flaherty

    Massachusetts General Hospital, United States

    67 publications · 36.8K citations

    45

    h-index

  3. AR
    Antoni Ribas

    University of California, Los Angeles, United States

    57 publications · 32.2K citations

    39

    h-index

  4. GA
    Grant A. McArthur

    Peter MacCallum Cancer Centre, Australia

    54 publications · 23.6K citations

    35

    h-index

  5. DS
    Dirk Schadendorf

    Heidelberg University, Germany

    49 publications · 29.9K citations

    34

    h-index

1–5 of 23.1K

Institutions

3.7K

  1. Memorial Sloan Kettering Cancer Center

    New York, United States

    85 h-index

    897 publications

    175.1K citations

  2. The University of Texas MD Anderson Cancer Center

    Houston, United States

    74 h-index

    927 publications

    130K citations

  3. Massachusetts General Hospital

    Boston, United States

    71 h-index

    537 publications

    143.1K citations

  4. Harvard University

    Cambridge, United States

    62 h-index

    686 publications

    137.1K citations

  5. Heidelberg University

    Heidelberg, Germany

    61 h-index

    602 publications

    115.9K citations

  6. German Cancer Research Center

    Heidelberg, Germany

    58 h-index

    418 publications

    59.1K citations

  7. University of California, San Francisco

    San Francisco, United States

    55 h-index

    532 publications

    71.6K citations

  8. Johns Hopkins University

    Baltimore, United States

    55 h-index

    519 publications

    84.8K citations

1–8 of 3.7K

Venues

  1. Journal of Clinical Oncology

    162 publications · 19.4K citations

    59

    h-index

  2. Clinical Cancer Research

    84 publications · 11.5K citations

    59

    h-index

  3. The Journal of Clinical Endocrinology & Metabolism

    JCEM · 49 publications · 7.4K citations

    43

    h-index

  4. Oncotarget

    88 publications · 3.7K citations

    37

    h-index

  5. PLoS ONE

    68 publications · 3.9K citations

    35

    h-index

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