A Systematic Screen for CDK4/6 Substrates Links FOXM1 Phosphorylation to Senescence Suppression in Cancer Cells

Lars Anders, Nan Rosemary Ke, Per Hydbring, +8

Cancer Cell

Tumor BiologySystematic ScreenSignal TransductionSignaling PathwayCell Regulation +12

Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers

Gregory R. Hoffman, Rami Rahal, Frank P. Buxton, +24

Proceedings of the National Academy of Sciences

The Histone H3K79 Methyltransferase Dot1L Is Essential for Mammalian Development and Heterochromatin Structure

Brendan T. Jones, Hui Su, Audesh Bhat, +11

PLoS Genetics

Histone ModificationsDot1-mediated H3k79 MethylationEpigenetic ChangeGeneticsCardiac Dilation +20

Acetylation of Sox2 Induces its Nuclear Export in Embryonic Stem Cells

Gretchen A. Baltus, Michael Kowalski, Huili Zhai, +4

Stem Cells

GeneticsGenomic MechanismEmbryonic StemEpigeneticsTranscriptional Regulation +16

Infrared Photodissociation Spectroscopy of Electrosprayed Ions in a Fourier Transform Mass Spectrometer

Han Bin Oh, Cheng Lin, Harold Y. Hwang, +5

Journal of the American Chemical Society

Development of secondary mutations in wild-type and mutant EZH2 alleles cooperates to confer resistance to EZH2 inhibitors

Veronica Gibaja, F Shen, J Harari, +13

Oncogene

GeneticsMolecular BiologyMolecular GeneticsEzh2 MutationsEpigenetics +19

Biosynthesis of the Thiazole Moiety of Thiamin Pyrophosphate (Vitamin B1)

Joo-Heon Park, Pieter C. Dorrestein, Huili Zhai, +3

Biochemistry

Bioorganic ChemistryEngineeringAldo-keto ReductaseMolecular BiologySecondary Metabolite +15

RAF Inhibitors Activate the MAPK Pathway by Relieving Inhibitory Autophosphorylation

Matthew Holderfield, Hanne Merritt, John S.D. Chan, +9

Cancer Cell

Synthesis of a well-defined glycoconjugate vaccine by a tyrosine-selective conjugation strategy

Qiying Hu, Martin Allan, Roberto Adamo, +12

Chemical Science

EngineeringAnti-candidiasis Glycoconjugate VaccineImmunologyGlycobiologyImmunodominance +17

HDAC4 Controls Muscle Homeostasis through Deacetylation of Myosin Heavy Chain, PGC-1α, and Hsc70

Liqing Luo, Sherry C. Martin, Jascha Parkington, +11

Cell Reports

Muscle FunctionMolecular RegulationHomeostatic MechanismMolecular BiologyHdac4 Inhibition +20