Gregory R. Hoffman

p53 inhibits CRISPR–Cas9 engineering in human pluripotent stem cells

Robert J. Ihry, Kathleen A. Worringer, Max R. Salick et al. · Nature Medicine · 2018 · 988 citations

Medicine, Stem Cell Engineering, Stem Cells +8

Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling

Yonghao Yu, Sang-Oh Yoon, George Poulogiannis et al. · Science · 2011 · 868 citations

Insulin Signaling, Signaling Pathway, Receptor Tyrosine Kinase +19

Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening

E. Robert McDonald, Antoine de Weck, Michael R. Schlabach et al. · Cell · 2017 · 687 citations · Full text

Bioinformatics, Tumor Biology, Radiation Oncology +13

Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5

Konstantinos J. Mavrakis, E. Robert McDonald, Michael R. Schlabach et al. · Science · 2016 · 538 citations

DNA Repair Profiling Reveals Nonrandom Outcomes at Cas9-Mediated Breaks

Megan van Overbeek, Daniel Capurso, Matthew M. Carter et al. · Molecular Cell · 2016 · 494 citations · Full text

Genome Instability, Dna Damage, Dna Analysis +4