A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene

Ji Luo, Michael J. Emanuele, Danan Li, +5

Cell

Ras OncogeneGeneticsNatural SciencesMolecular BiologyGene Expression +4

Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening

E. Robert McDonald, Antoine de Weck, Michael R. Schlabach, +96

Cell

BioinformaticsTumor BiologyRadiation OncologyFunctional GenomicsProject Drive +11

Second-generation shRNA libraries covering the mouse and human genomes

José M. Silva, Mamie Z. Li, Ken C. N. Chang, +17

Nature Genetics

Second-generation Shrna LibrariesGeneticsSmall RnaMedicineFunctional Genomics +3

Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5

Konstantinos J. Mavrakis, E. Robert McDonald, Michael R. Schlabach, +41

Science

Studying clonal dynamics in response to cancer therapy using high-complexity barcoding

Hyo-Eun Carrie Bhang, David A. Ruddy, Viveksagar Krishnamurthy Radhakrishna, +20

Nature Medicine

High-complexity BarcodingTumor BiologyCancer TherapySystems BiologyEngineering +12

A Genetic Screen for Candidate Tumor Suppressors Identifies REST

Thomas F. Westbrook, Eric S. Martin, Michael R. Schlabach, +10

Cell

GeneticsCancer GenomicsGenetic ScreenTumor SuppressorCancer Genetics +3

A SUMOylation-Dependent Transcriptional Subprogram Is Required for Myc-Driven Tumorigenesis

Jessica D. Kessler, Kristopher T. Kahle, Tingting Sun, +23

Science

Transcriptional RegulationSystems BiologyCell RegulationOncogenic AgentMedicine +12

Cancer Proliferation Gene Discovery Through Functional Genomics

Michael R. Schlabach, Ji Luo, Nicole L. Solimini, +14

Science

Systems BiologyFunctional GenomicsSingle Cell SequencingParallel Multiplex MethodologyCancer Genomics +10

CRISPR Screens Provide a Comprehensive Assessment of Cancer Vulnerabilities but Generate False-Positive Hits for Highly Amplified Genomic Regions

Diana M. Muñoz, Pamela J. Cassiani, Li Li, +23

Cancer Discovery

Tumor-derived IFN triggers chronic pathway agonism and sensitivity to ADAR loss

Huayang Liu, Javad Golji, Lauren K. Brodeur, +16

Nature Medicine

MedicineImmunologyPathologyCancer GenomicsAdar Loss +6