Profiling of Estrogen Up- and Down-Regulated Gene Expression in Human Breast Cancer Cells: Insights into Gene Networks and Pathways Underlying Estrogenic Control of Proliferation and Cell Phenotype

Jonna Frasor, Jeanne M. Danes, Barry S. Komm, +3

Endocrinology

Breast OncologyGlobal Gene ExpressionEstrogen Up-Gene Regulatory NetworkGene Expression Profiling +15

Second-generation shRNA libraries covering the mouse and human genomes

José M. Silva, Mamie Z. Li, Ken C. N. Chang, +17

Nature Genetics

Second-generation Shrna LibrariesGeneticsSmall RnaMedicineFunctional Genomics +3

Genome-Wide Analysis of Estrogen Receptor α DNA Binding and Tethering Mechanisms Identifies Runx1 as a Novel Tethering Factor in Receptor-Mediated Transcriptional Activation

Joshua D. Stender, Kyuri Kim, Tze Howe Charn, +6

Molecular and Cellular Biology

Receptor-mediated Transcriptional ActivationNovel Tethering FactorGeneticsEpigeneticsTranscriptional Regulation +19

Estrogen-Regulated Gene Networks in Human Breast Cancer Cells: Involvement of E2F1 in the Regulation of Cell Proliferation

Joshua D. Stender, Jonna Frasor, Barry S. Komm, +3

Molecular Endocrinology

Estrogen-regulated Gene NetworksBreast OncologyCell RegulationMedicineHormonal Receptor +12

LXR modulation blocks prostaglandin E ₂ production and matrix degradation in cartilage and alleviates pain in a rat osteoarthritis model

Ning Li, M.A. Rivera-Bermudez, Mei Zhang, +10

Proceedings of the National Academy of Sciences

Differential Biochemical and Cellular Actions of Premarin Estrogens: Distinct Pharmacology of Bazedoxifene-Conjugated Estrogens Combination

Thomas J. Berrodin, Ken C. N. Chang, Barry S. Komm, +2

Molecular Endocrinology

Hormonal ContraceptiveGynecologyFemale Reproductive FunctionPharmacotherapyOvarian Cancer +18

Gene expression profiling studies of three SERMs and their conjugated estrogen combinations in human breast cancer cells: Insights into the unique antagonistic effects of bazedoxifene on conjugated estrogens

Ken C. N. Chang, Yihe Wang, Peter V.N. Bodine, +2

The Journal of Steroid Biochemistry and Molecular Biology

Breast OncologyConjugated Estrogen CombinationsConjugated EstrogensMedicineHormonal Receptor +6

Liver X Receptor Is a Therapeutic Target for Photoaging and Chronological Skin Aging

Ken C. N. Chang, Qi Shen, Inn Gyung Oh, +10

Molecular Endocrinology

DermatologyChronological Skin AgingLiver X ReceptorOxidative StressInflammation +17

Liver X Receptor-Retinoid X Receptor (LXR-RXR) Heterodimer Cistrome Reveals Coordination of LXR and AP1 Signaling in Keratinocytes

Qi Shen, Yuchen Bai, Ken C. N. Chang, +5

Journal of Biological Chemistry

Molecular RegulationDermatologyTranscriptional RegulationSignaling PathwayCell Regulation +18

Estrogen Receptor β Is a Novel Therapeutic Target for Photoaging

Ken C. N. Chang, Yihe Wang, Inn Gyung Oh, +5

Molecular Pharmacology