David A. Ruddy

A novel MHC class I–like gene is mutated in patients with hereditary haemochromatosis

John N. Feder, Andreas Gnirke, Zenta Tsuchihashi et al. · Nature Genetics · 1996 · 3.7K citations

Life Sciences, Genetics, Molecular Genetics +12

High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response

Hui Gao, Joshua M. Korn, Stéphane Ferretti et al. · Nature Medicine · 2015 · 1.4K citations

Medicine, Oncology, Pharmacology +12

Tumor cells can follow distinct evolutionary paths to become resistant to epidermal growth factor receptor inhibition

Aaron N. Hata, Matthew J. Niederst, Hannah L. Archibald et al. · Nature Medicine · 2016 · 999 citations · Full text

Medicine, Cancer Biology, Oncology +15

aph-1 and pen-2 Are Required for Notch Pathway Signaling, γ-Secretase Cleavage of βAPP, and Presenilin Protein Accumulation

Ross S. Francis, Garth McGrath, Jianhua Zhang et al. · Developmental Cell · 2002 · 796 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +6

Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening

E. Robert McDonald, Antoine de Weck, Michael R. Schlabach et al. · Cell · 2017 · 701 citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +17