Concepedia

aph-1 and pen-2 Are Required for Notch Pathway Signaling, γ-Secretase Cleavage of βAPP, and Presenilin Protein Accumulation

Ross S. Francis, Garth McGrath, Jianhua Zhang, David A. Ruddy, Mary Sym, Javier Apfeld, Monique Nicoll, Mark Maxwell, Bing Hai, Michael C. Ellis,

Developmental Cell · 2002 · 796 citations · 42 references

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42

A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain

Bart De Strooper, Wim Annaert, Philippe Cupers et al. · Nature · 1999 · 2.1K citations

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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity

Michael S. Wolfe, Weiming Xia, Beth L. Ostaszewski et al. · Nature · 1999 · 1.9K citations

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Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

Eric H. Schroeter, Jeffrey A. Kisslinger, Raphael Kopan · Nature · 1998 · 1.6K citations

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Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity

Riqiang Yan, Michael J. Bienkowski, Mary E. Shuck et al. · Nature · 1999 · 1.4K citations

, , +14

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and βAPP processing

Gang Yu, Masaki Nishimura, Shigeki Arawaka et al. · Nature · 2000 · 904 citations

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