Bart De Strooper

A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain

Bart De Strooper, Wim Annaert, Philippe Cupers et al. · Nature · 1999 · 2.1K citations

Protein Secretion, Protein Function, Signal Transduction +8

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

Bart De Strooper, Paul Säftig, Katleen Craessaerts et al. · Nature · 1998 · 1.8K citations

Neurodegenerative Diseases, Alzheimer's Disease, Molecular Biology +9

OPA1 Controls Apoptotic Cristae Remodeling Independently from Mitochondrial Fusion

Christian Frezza, Sara Cipolat, Olga Martins de Brito et al. · Cell · 2006 · 1.6K citations · Full text

Signal Transduction, Mitochondrial Function, Medicine +3

Cholesterol depletion inhibits the generation of β-amyloid in hippocampal neurons

Mikael Simons, Patrick Keller, Bart De Strooper et al. · Proceedings of the National Academy of Sciences · 1998 · 1.1K citations · Full text

Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/β-secretase expression

Sébastien S. Hébert, Katrien Horré, Laura Nicolaï et al. · Proceedings of the National Academy of Sciences · 2008 · 1.1K citations · Full text

Sporadic Alzheimer, Brain Development, Psen Genes +17