Philippe Cupers

A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain

Bart De Strooper, Wim Annaert, Philippe Cupers et al. · Nature · 1999 · 2.1K citations

Protein Secretion, Protein Function, Signal Transduction +8

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

An Herreman, Dieter Hartmann, Wim Annaert et al. · Proceedings of the National Academy of Sciences · 1999 · 521 citations · Full text

The amyloid precursor protein (APP)‐cytoplasmic fragment generated by γ‐secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture

Philippe Cupers, Isabelle Orlans, Katleen Craessaerts et al. · Journal of Neurochemistry · 2001 · 229 citations

Interaction with Telencephalin and the Amyloid Precursor Protein Predicts a Ring Structure for Presenilins

Wim Annaert, Cary Esselens, Veerle Baert et al. · Neuron · 2001 · 187 citations · Full text

Neurodegenerative Diseases, Alzheimer's Disease, Molecular Neuroscience +8

The discrepancy between presenilin subcellular localization and <b>γ</b>-secretase processing of amyloid precursor protein

Philippe Cupers, Mustapha Bentahir, Katleen Craessaerts et al. · The Journal of Cell Biology · 2001 · 158 citations · Full text