Michael S. Wolfe

A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain

Bart De Strooper, Wim Annaert, Philippe Cupers et al. · Nature · 1999 · 2.1K citations

Protein Secretion, Protein Function, Signal Transduction +8

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity

Michael S. Wolfe, Weiming Xia, Beth L. Ostaszewski et al. · Nature · 1999 · 1.9K citations

Protein Secretion, Presenilin Endoproteolysis, Biochemistry +13

<i>c-Myc</i> is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma

Andrew P. Weng, John M. Millholland, Yumi Yashiro–Ohtani et al. · Genes & Development · 2006 · 879 citations · Full text

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

W. Taylor Kimberly, Matthew J. LaVoie, Beth L. Ostaszewski et al. · Proceedings of the National Academy of Sciences · 2003 · 750 citations · Full text

Transition-state analogue inhibitors of γ-secretase bind directly to presenilin-1

William P. Esler, W. Taylor Kimberly, Beth L. Ostaszewski et al. · Nature Cell Biology · 2000 · 518 citations

Molecular Pharmacology, Protein Secretion, Transition-state Analogue Inhibitors +3