Concepedia
Statistics
Publications
103
Citations
14K
H-Index
49
Active since
1977
Affiliations
Brigham and Women's Hospital(Current)
Harvard University
University of Kansas
University of Tennessee Health Science Center
Massachusetts General Hospital
Michael S. Wolfe is an author at Brigham and Women's Hospital specializing in life sciences, enzymology, and biochemistry.
Publications per year
1977–2024
A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain
Bart De Strooper, Wim Annaert, Philippe Cupers et al. · Nature · 1999 · 2.1K citations
Life Sciences, Cell Biology, Molecular Biology +12
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity
Michael S. Wolfe, Weiming Xia, Beth L. Ostaszewski et al. · Nature · 1999 · 1.9K citations
Life Sciences, Biochemistry, Molecular Biology +8
<i>c-Myc</i> is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma
Andrew P. Weng, John M. Millholland, Yumi Yashiro–Ohtani et al. · Genes & Development · 2006 · 885 citations · Full text
Life Sciences, Cell Biology, Oncology +13
γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2
W. Taylor Kimberly, Matthew J. LaVoie, Beth L. Ostaszewski et al. · Proceedings of the National Academy of Sciences · 2003 · 758 citations
Life Sciences, Biochemistry, Molecular Biology +16
Transition-state analogue inhibitors of γ-secretase bind directly to presenilin-1
William P. Esler, W. Taylor Kimberly, Beth L. Ostaszewski et al. · Nature Cell Biology · 2000 · 520 citations
Life Sciences, Biochemistry, Medicinal Chemistry +13
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