W. Taylor Kimberly

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity

Michael S. Wolfe, Weiming Xia, Beth L. Ostaszewski et al. · Nature · 1999 · 1.9K citations

Protein Secretion, Presenilin Endoproteolysis, Biochemistry +13

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

W. Taylor Kimberly, Matthew J. LaVoie, Beth L. Ostaszewski et al. · Proceedings of the National Academy of Sciences · 2003 · 750 citations · Full text

Transition-state analogue inhibitors of γ-secretase bind directly to presenilin-1

William P. Esler, W. Taylor Kimberly, Beth L. Ostaszewski et al. · Nature Cell Biology · 2000 · 518 citations

Molecular Pharmacology, Protein Secretion, Transition-state Analogue Inhibitors +3

Recommendations for the Management of Cerebral and Cerebellar Infarction With Swelling

Eelco F. M. Wijdicks, Kevin N. Sheth, Bob S. Carter et al. · Stroke · 2014 · 508 citations · Full text

The Intracellular Domain of the β-Amyloid Precursor Protein Is Stabilized by Fe65 and Translocates to the Nucleus in a Notch-like Manner

W. Taylor Kimberly, Jessica B. Zheng, Suzanne Y. Guénette et al. · Journal of Biological Chemistry · 2001 · 437 citations · Full text