Weiming Xia

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity

Michael S. Wolfe, Weiming Xia, Beth L. Ostaszewski et al. · Nature · 1999 · 1.9K citations

Protein Secretion, Presenilin Endoproteolysis, Biochemistry +13

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice

Martin Citron, David Westaway, Weiming Xia et al. · Nature Medicine · 1997 · 1.3K citations

Neurodegenerative Diseases, Alzheimer's Disease, Molecular Neuroscience +12

Skeletal and CNS Defects in Presenilin-1-Deficient Mice

Jie Shen, Roderick T. Bronson, Dongfeng Chen et al. · Cell · 1997 · 956 citations · Full text

Knockout Mouse, Sclerostin, Developmental Biology +5

Increased App Expression in a Mouse Model of Down's Syndrome Disrupts NGF Transport and Causes Cholinergic Neuron Degeneration

Ahmad Salehi, Jean‐Dominique Delcroix, Pavel V. Belichenko et al. · Neuron · 2006 · 541 citations · Full text

Down Syndrome, Neurodegenerative Diseases, Molecular Neuroscience +11

Transition-state analogue inhibitors of γ-secretase bind directly to presenilin-1

William P. Esler, W. Taylor Kimberly, Beth L. Ostaszewski et al. · Nature Cell Biology · 2000 · 518 citations

Molecular Pharmacology, Protein Secretion, Transition-state Analogue Inhibitors +3