David Westaway

A cellular gene encodes scrapie PrP 27-30 protein

Bruno Oesch, David Westaway, Monika Wälchli et al. · Cell · 1985 · 1.5K citations

Natural Sciences, Genetics, Medicine +6

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice

Martin Citron, David Westaway, Weiming Xia et al. · Nature Medicine · 1997 · 1.3K citations

Neurodegenerative Diseases, Alzheimer's Disease, Molecular Neuroscience +12

The cellular prion protein binds copper in vivo

David R. Brown, Kefeng Qin, Jochen Herms et al. · Nature · 1997 · 1.3K citations

Biochemistry, Natural Sciences, Metalloprotein +5

Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

Ju‐Hyun Lee, Wai Haung Yu, Asok Kumar et al. · Cell · 2010 · 1.2K citations · Full text

Cell Autophagy, Mitophagy, Lysosomal Proteolysis +12

Early-onset Amyloid Deposition and Cognitive Deficits in Transgenic Mice Expressing a Double Mutant Form of Amyloid Precursor Protein 695

M. Azhar Chishti, Dun-Shen Yang, Christopher Janus et al. · Journal of Biological Chemistry · 2001 · 947 citations · Full text